ISWI Chromatin Modelling Complex: A Promising Drug Target (P28654)

Target Name: ISWI Chromatin Remodeling Complex

NCBI ID: P28654

ISWI Chromatin Remodeling Complex

Other Name(s): None

ISWI Chromatin Modelling Complex: A Promising Drug Target

ISWI (Immunomodulatory System-Regulated Inhibitor of DNA-Protein binding) chromatin remodeling complex is a protein complex that plays a crucial role in regulating immune responses and cellular processes that are critical for tissue growth and development. The ISWI chromatin remodeling complex is composed of several subunits that are responsible for modifying the chromatin structure and paving the way for various cellular processes.

The ISWI chromatin remodeling complex is a well-established drug target and has been identified as a potential biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Its role in modulating immune responses and cellular processes makes it an attractive target for researchers to study and develop new therapeutic approaches.

Structure and Function

The ISWI chromatin remodeling complex is a protein complex that contains several subunits, including ISWI-1, ISWI-2, ISWI-3, ISWI-4, ISWI-5, and ISWI-6. These subunits are involved in various cellular processes, including DNA replication, transcription, and repair, and are responsible for modifying the chromatin structure and paving the way for various cellular processes.

One of the key functions of the ISWI chromatin remodeling complex is its ability to alter the chromatin structure. ISWI-1 and ISWI-2 are involved in the removal of a type of DNA molecule called histone H3, which is the protein that makes up the nucleotide. This process is known as histone remodeling and is critical for the regulation of gene expression.

Another function of the ISWI chromatin remodeling complex is its ability to alter the chromatin structure in response to various chemical modifications, such as DNA methylation and histone acetylation. These modifications play a critical role in the regulation of gene expression and are involved in the development and maintenance of various cellular processes.

The ISWI chromatin remodeling complex is also involved in the regulation of cellular processes that are critical for tissue growth and development. For example, ISWI-5 and ISWI-6 are involved in the regulation of cell division and the maintenance of stem cell properties, while ISWI-4 is involved in the regulation of DNA replication and repair.

Drug Targeting

The ISWI chromatin remodeling complex is a well-established drug target and has been identified as a potential biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Its role in modulating immune responses and cellular processes makes it an attractive target for researchers to study and develop new therapeutic approaches.

One of the key strategies for targeting the ISWI chromatin remodeling complex is the use of small molecules that can modulate its activity. These small molecules can interact with the various subunits of the ISWI chromatin remodeling complex and alter its function.

For example, a number of small molecules have been shown to interact with the ISWI chromatin remodeling complex and modulate its activity. These small molecules include inhibitors of DNA-protein binding, such as in and suzukin, as well as drugs that can alter the chromatin structure, such as histone acetylation inhibitors and DNA methylation inhibitors.

Another approach for targeting the ISWI chromatin remodeling complex is the use of antibodies that can specifically recognize and interact with its subunits. These antibodies can be used to block the activity of the ISWI chromatin remodeling complex and prevent it from modulating chromatin structure and regulating cellular processes.

Clinical Applications

The ISWI chromatin remodeling complex is a potential drug target and has been identified as a potential biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Its role in modulating immune responses and cellular processes makes it an attractive target for

Protein Name: ISWI Chromatin Remodeling Complex

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